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Slc22A17 Antibody

CAT: 0223-4651-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4651-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Slc22A17 Antibody: The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na (+) /l-carnitine cotransporter (OCTN2) . Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.
NCBI Gene ID
51310
Swiss Prot
Q8WUG5
Accession Number
Q8WUG5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
Slc22A17 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (86%)
Buffer
Slc22A17 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Slc22A17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SLC22A17
NCBI Official Name
Solute carrier family 22, member 17
NCBI Organism
Homo sapiens
Background Reference 01
Koepsell H and Endou H. The SLC22 drug transporter family. Pflugers Arch. 2004; 447:666-76.
Background Reference 02
Rizwan AN and Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm. Res. 2007; 24:450-70.
Background Reference 03
Miharada K, Hiroyama T, Sudo K, et. al. Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells. J. Cell Physiol. 2008; 215:526-37.
Background Reference 04
Devireddy LR, Gazin C, Zhu X, et al. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 2005; 123:1293-305.
Other Product Names
Slc22A17 Antibody: BOCT, BOIT, 24p3R, NGALR, hBOIT, NGALR2, NGALR3, BOCT, Solute carrier family 22 member 17, 24p3 receptor
Tested Applications
ELISA, WB, IF, IHC-P
Protein ID
27805426
Physical Properties
Liquid

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