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Wnt10a Antibody

CAT: 0223-4639-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4639-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Wnt10a Antibody: Wnt10a is a member of the Wnt family, a gene family that encodes secreted signaling proteins that play crucial roles in normal development such as regulation of cell fate and patterning during embryogenesis as well as neoplastic transformation. Elevated levels of Wnt10a have been detected in several human tumors and cancer cell lines including colorectal cancer and chronic lymphocytic leukemia and it has been suggested that uncontrolled Wnt signaling may contribute to the defect in apoptosis that characterizes these malignancies. Recently, a mutation in Wnt10a was found to be associated with odonto-onycho-dermal dysplasia, an autosomal recessive ectodermal dysplasia.
NCBI Gene ID
80326
Swiss Prot
Q9GZT5
Accession Number
Q9GZT5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Cancer
Purification
Wnt10a Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1283 - RAW 264.7 Cell Lysate
Concentration
1 mg/mL
Buffer
Wnt10a Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Wnt10a antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This Wnt10a antibody is predicted to not cross-react with Wnt10b.
Symbol
WNT10A
NCBI Official Name
Wingless-type MMTV integration site family, member 10A
NCBI Organism
Homo sapiens
Background Reference 01
Kelly GM, Lai CJ, and Moon RT. Expression of wnt10a in the central nervous system of developing zebrafish. Dev. Biol. 1993; 158:113-21.
Background Reference 02
Nusse R and Varmus RE. Wnt genes. Cell 1992; 69:1073-87.
Background Reference 03
Kirikoshi H, Sekihara H, and Katoh M. WNT10A and WNT6, clustered in human chromosome 2q35 region head-to-tail manner, are strongly coexpressed in SW480 cells. Biochem. Biophys. Res. Commun. 2001; 283:798-805.
Background Reference 04
Kirikoshi H, Inoue S, Sekihara H, et al. Expression of WNT10A in human cancer. Int. J. Oncol. 2001; 19:997-1001.
Other Product Names
Wnt10a Antibody: OODD, SSPS, STHAG4, Protein Wnt-10a
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
14424011
Physical Properties
Liquid

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