SATB2 Antibody

• Background :

  SATB2 Antibody: Human special AT-rich sequence-binding protein-2 (SATB2) is a nuclear matrix/scaffold-associated region DNA-binding protein. Like its homolog SATB1, SATB2 selectively binds double-stranded, special AT-rich DNA sequences, but is expressed primarily in a subset of postmitotic, differentiating neurons in the neocortex. Mice deficient in SATB exhibit craniofacial abnormalities and defects in osteoblast differentiation and function. SATB2 also interacts with and enhances the activity of Runx2 and ATF4, two transcription factors that regulate osteoblast differentiation, indicating that SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Recent experiments have shown that SATB2 interacts with histone deacetylase 1 and metastasis-associated protein 2, two proteins that are involved in chromatin remodeling, suggesting that SATB2 may also be involved in mediating epigenetic influences during cortical development.

• NCBI Gene ID :

  23314

• Swiss Prot :

  Q9UPW6

• Accession Number :

  Q9UPW6

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  SATB2 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1403 - Mouse Brain Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  SATB2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  SATB2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  At least two isoforms of SATB2 are known to exist. This SATB2 antibody will not cross-react with SATB1.

• Symbol :

  SATB2

• Positive Control 2 :

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name :

  SATB homeobox 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Dickinson LA and Kohwi-Shigematsu T. Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-unpairing potential. Mol. Cell. Biol.1995; 15:456-65.

• Background Reference 02 :

  Szemes M, Gyorgy A, Pawaletz C, et al. Isolation and characterization of SATB2, a novel AT-rich DNA binding protein expressed in development- and cell-specific manner in the rat brain. Neurochem. Res.2006; 31:237-46.

• Background Reference 03 :

  Dobreva G, Chahour M, Dautzenberg M, et al. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell2006; 125:971-86.

• Background Reference 04 :

  Gyorgy AB, Szemes M, de Jaun Romero C, et al. SATB2 interacts with chromatin-remodeling molecules in differentiating cortical neurons. Eur. J. Neurosci.2008; 27:865-73.

• Other Product Names :

  SATB2 Antibody: KIAA1034, DNA-binding protein SATB2, Special AT-rich sequence-binding protein 2

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  13634020

• Physical Properties :

  Liquid