CAPS2 Antibody

• Background:

  CAPS2 Antibody: CAPS2 and the related protein CAPS1 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. Like CAPS1, numerous isoforms of CAPS2 are known to exist. These isoforms show distinct expression patterns in the brain. For example, CAPS2b showed high expression in the developing cerebellum. Furthermore, one version of CAPS2 mRNA that lacks exon 3 is detected in some autistic patients, suggesting that the differential expression pattern of CAPS2 is involved in neuronal development.

• NCBI Gene ID:

  93664

• Swiss Prot:

  Q86UW7

• Accession Number:

  NP_060424

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  CAPS2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  CAPS2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  CAPS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  Multiple isoforms of CAPS2 are known to exist. This CAPS2 antibody is predicted to be specific to CAPS2 and not recognize CAPS1.

• Symbol:

  CADPS2

• Positive Control 2:

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name:

  Ca++-dependent secretion activator 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Walent JH, Porter BW, and Martin TF. A novel 145 kD brain cytosolic protein reconstitutes Ca (2+) -regulated secretion in permeable neuroendocrine cells. Cell 1992; 70:765-775.

• Background Reference 02:

  Juckusch WJ, Speidel D, Sigler A, et al. CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell 2007; 131:796-808.

• Background Reference 03:

  Sadakata T, Washida M, and Furuichi T. Alternative splicing variants in mouse CAPS2: differential expression and functional properties of splicing variants. BMC Neurosci. 2007; 8:25-35.

• Other Product Names:

  CAPS2 Antibody: CAPS2, KIAA1591, Calcium-dependent secretion activator 2, Calcium-dependent activator protein for secretion 2, CAPS-2

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  148839294

• Physical Properties:

  Liquid