EVER1 Antibody

CAT: 0223-4549-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4549-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EVER1 Antibody: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.
NCBI Gene ID
11322
Swiss Prot
Q7Z403
Accession Number
AAM44452
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
EVER1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
EVER1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
EVER1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
Symbol
TMC6
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Transmembrane channel-like 6
NCBI Organism
Homo sapiens
Background Reference 01
Majewski S, Jablonska J and Orth G. Epidermodysplasia verruciformis. Immunological and nonimmunological surveillance mechanisms: role in tumor progression. Clin. Dermatol.1997; 15:321-34.
Background Reference 02
Ramoz N, Rueda L-A, Bouadjar B, et al. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat. Genetics2002; 32:579-81.
Background Reference 03
Keresztes G, Mutai H and Heller S. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. BMC Genomics2003; 4:24-34.
Background Reference 04
Lazarczyk L, Pons C, Mendoza JA, et al. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. J. Exp. Med.2008; 205:35-42.
Other Product Names
EVER1 Antibody: EV1, EVER1, EVIN1, LAK-4P, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
25527208
Physical Properties
Liquid

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Alternative Products

CatalogName
OAPB00659-100UGEVER1 Antibody
A07322Anti-EVER1 TMC6 Antibody
OAPB00659-100UG-HRPEVER1 Antibody : HRP (OAPB00659-HRP)
OAPB00658-100UG-BiotinEVER1 Antibody : Biotin (OAPB00658-Biotin)
OAPB00659-100UG-BiotinEVER1 Antibody : Biotin (OAPB00659-Biotin)
OAPB00658-100UG-FITCEVER1 Antibody : FITC (OAPB00658-FITC)
OAPB00658-100UG-HRPEVER1 Antibody : HRP (OAPB00658-HRP)
OAPB00659-100UG-FITCEVER1 Antibody : FITC (OAPB00659-FITC)
MBS151974-01EVER1 Peptide
MBS646809-01TMC6, NT (Transmembrane Channel-Like Protein 6, Epidermodysplasia Verruciformis Protein 1, Protein LAK-4, EVER1, EVIN1)

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