LGI2 Antibody

CAT: 0223-4533-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4533-01Size:0.02 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LGI2 Antibody: The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.
NCBI Gene ID
246316
Swiss Prot
Q8K4Z0
Accession Number
Q8N0V4
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
LGI2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1404 - Mouse Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
LGI2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LGI2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins.Three isoforms of LGI2 are known to exist; this LGI2 antibody will recognize only the longest.
Symbol
Lgi2
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Leucine-rich repeat LGI family, member 2
NCBI Organism
Mus musculus
Background Reference 01
Gu W, Gibert Y, Wirth T, et al. Using gene-history and expression analysis to assess the involvement of LGI genes in human disorders. Mol. Biol. Evol.2005; 22:2209-16.
Background Reference 02
Chernova OB, Somerville RP and Cowell JK. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene1998; 17:2873-81.
Background Reference 03
Berkovic SF, Izzillo P, McMahon JM, et al. LGI1 mutations in temporal lobe epilepsies. Neurology2004; 62:1115-9.
Other Product Names
LGI2 Antibody: mKIAA1916, Kiaa1916, Leucine-rich repeat LGI family member 2, Leucine-rich glioma-inactivated protein 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
32469737
Physical Properties
Liquid

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