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Grik2 Antibody

CAT: 0223-4387-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4387-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Grik2 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Recent reports have suggested that defects in the Grik2 protein may be associated with autosomal recessive mental retardation and possibly other neurological disorders such as schizophrenia. Numerous isoforms of Grik2 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow. This Grik2 antibody may exhibit some cross-reactivity to Grik3.
NCBI Gene ID
2898
Swiss Prot
Q13002
Accession Number
Q13002
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Grik2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
Grik2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Grik2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
GRIK2
NCBI Official Name
Glutamate receptor, ionotropic, kainate 2
NCBI Organism
Homo sapiens
Background Reference 01
Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.
Background Reference 02
Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
Background Reference 03
Paschen W, Blackstone CD, Huganir RL, et al. Human GluR6 kainate receptor (GRIK2) : molecular cloning, expression, polymorphism, and chromosomal assignment. Genomics1994; 20:435-40.
Background Reference 04
Motazacker MM, Rost BR, Hucho T, et al. A defect in the ionotrophic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation. Am. J. Hum. Genet.2007; 81:792-8.
Other Product Names
Grik2 Antibody: EAA4, GLR6, MRT6, GLUK6, GLUR6, GluK2, Glutamate receptor ionotropic, kainate 2, Excitatory amino acid receptor 4
Tested Applications
ELISA, WB
Protein ID
2492627
Physical Properties
Liquid

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