FEZ1 Antibody

• Background:

  FEZ1 Antibody: Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC) -Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist.

• NCBI Gene ID:

  9638

• Swiss Prot:

  Q99689

• Accession Number:

  Q99689

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  FEZ1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1207 - Raji Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  FEZ1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  FEZ1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  FEZ1

• NCBI Official Name:

  Fasciculation and elongation protein zeta 1 (zygin I)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kuroda S, Nakagawa N, Tokunaga C, et al. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C z-interacting protein. J. Cell Biol.1999; 144:403-11.

• Background Reference 02:

  Bloom L and Horvitz HR. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proc. Natl. Acad. Sci. USA1997; 88:9578-82.

• Background Reference 03:

  Miyohi K, Honda A, Baba K, et al. Disrupted-in-schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol. Psychiatry2003; 8:685-94.

• Background Reference 04:

  Blasius TL, Cai D, Jih GT, et al. Two binding partners cooperate to activate the molecular motor kinesin-1. J. Cell Biol.2007; 176:11-7.

• Other Product Names:

  FEZ1 Antibody: Fasciculation and elongation protein zeta-1, Zygin I

• Tested Applications:

  ELISA, WB

• Protein ID:

  13431526

• Physical Properties:

  Liquid