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IFN-beta Antibody

CAT: 0223-4243-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4243-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IFN-beta Antibody: Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
NCBI Gene ID
3456
Swiss Prot
P01574
Accession Number
AAC41702
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
4243
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar IFN-beta expression profile in human and mouse cell lines detected by two independent anti-IFN-beta antibodies that recognize different epitopes, 4243 against central domain and 64-239 against human recombinant protein. IFN-beta proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines4243 64-239 Recombinant Protein Test (Figure 3) : Anti-IFN-beta antibodies (4243) detected human IFN-beta recombinant protein. Recombinant Protein Test4243
Field of Research
Immunology, Inflammasomes
Purification
IFN-beta Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
IFN-beta Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IFN-beta antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human IFN-beta has one (187aa, 22kD) . Mouse IFN-beta has one isoform (182aa, 22kD) and Rat IFN-beta also has one isoform (184aa, 22kD) . 4243 can detect human isoform, and possibly detect mouse and rat.
Symbol
IFNB1
Positive Control 2
Cat. No. 1304 - Human Liver Tissue Lysate
Positive Control 3
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Interferon, beta 1, fibroblast
NCBI Organism
Homo sapiens
Background Reference 01
Gresser. J. Leuk. Biol.1997; 61:567-74.
Background Reference 02
Colonna. Eur. J. Immunol.2007; 37:306-9.
Background Reference 03
Kock et al. Ann. Neurol.2007; epub.
Other Product Names
IFN-beta Antibody: IFB, IFF, IFNB, IFB, Interferon beta, Fibroblast interferon, IFN-beta
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
184623
Physical Properties
Liquid

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