Products for Research Use Only
RegisterLogin

CRTH2 Antibody

CAT: 0223-4027-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-4027-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
CRTH2 Antibody: The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.
NCBI Gene ID
11251
Swiss Prot
Q9Y5Y4
Accession Number
NP_004769
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
CRTH2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/mL
Buffer
CRTH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CRTH2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two different isoforms of CRTH2 are known to exist; this antibody will detect both isoforms.
Symbol
PTGDR2
Positive Control 2
Cat. No. 1301 - Human Heart Tissue Lysate
Positive Control 3
Cat. No. 10-501 - Human Heart Tissue Slide
NCBI Official Name
Prostaglandin D2 receptor 2
NCBI Organism
Homo sapiens
Background Reference 01
Nagata K, Hirai K, Tanaka K, et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor (s) . FEBS Lett. 1999; 459:195-9.
Background Reference 02
Shichijo M, Sugimoto H, Nagao K, et al. Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockage abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats. J. Pharmacol. Exp. Ther. 2003; 307:518-25.
Background Reference 03
Chevalier E, Stock J, Fisher T, et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J. Immunol. 2005; 2056-60.
Other Product Names
CRTH2 Antibody: DP2, DL1R, CD294, CRTH2, GPR44, Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
153791424
Physical Properties
Liquid

Related Products

CatalogName
4027PCRTH2 Peptide
4029PCRTH2 Peptide
7325-01CRTC2 Antibody
43-309CRTC2 Antibody
7325-01mgCRTC2 Antibody
7325-002mgCRTC2 Antibody
42-852CRTC2 Antibody
42-443Crtc2 Antibody
42-407CRTC2 Antibody
42-407PCRTC2 Peptide

Alternative Products

CatalogName
MBS536206-01CRTH2 antibody
BZ16089-01CRTH2 polyclonal antibody
GTR18222701GPR44/CRTH2 Antibody
APR15605GPolyclonal CRTH2 Antibody
A12856-1Anti-CRTH2 PTGDR2 Antibody
APRab00521-01CRTH2 Rabbit Polyclonal Antibody
GTR18188251-01Mouse Monoclonal human CRTH2 Antibody
APR16572GPolyclonal GPR44 / CRTH2 Antibody (Extracellular Domain)
APR16575GPolyclonal GPR44 / CRTH2 Antibody (N-Terminus)
GTR19206145-01CRTH2-IN-1

Popular Products