CRTH2 Antibody

• Background :

  CRTH2 Antibody: The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.

• NCBI Gene ID :

  11251

• Swiss Prot :

  Q9Y5Y4

• Accession Number :

  NP_004769

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  CRTH2 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  CRTH2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  CRTH2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  At least two different isoforms of CRTH2 are known to exist; this antibody will detect both isoforms.

• Symbol :

  PTGDR2

• Positive Control 2 :

  Cat. No. 1301 - Human Heart Tissue Lysate

• Positive Control 3 :

  Cat. No. 10-501 - Human Heart Tissue Slide

• NCBI Official Name :

  Prostaglandin D2 receptor 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Nagata K, Hirai K, Tanaka K, et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor (s) . FEBS Lett. 1999; 459:195-9.

• Background Reference 02 :

  Shichijo M, Sugimoto H, Nagao K, et al. Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockage abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats. J. Pharmacol. Exp. Ther. 2003; 307:518-25.

• Background Reference 03 :

  Chevalier E, Stock J, Fisher T, et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J. Immunol. 2005; 2056-60.

• Other Product Names :

  CRTH2 Antibody: DP2, DL1R, CD294, CRTH2, GPR44, Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  153791424

• Physical Properties :

  Liquid