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TSLP Antibody

CAT: 0223-4021-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4021-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TSLP Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. At least two differentially spliced isoforms of TSLP are known to exist.
NCBI Gene ID
85480
Swiss Prot
Q969D9
Accession Number
NP_149024
Host
Rabbit
Reactivity
Human
Immunogen
4021
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Validation (Figure 1) : Anit-TSLP antibodies (4021) detected human TSLP recombinant protein at different concentrations. Recombinant Protein Validation4021 Regulated Expression Validation (Figure 4-8) : Anit-TSLP antibodies (4021) detected increased expression in multiple tissue or cells after treatment with cytokines or chemicals, in which the increase in the expression was inhibited by co-treatment with anti-cholinergic drugs (Figure 5) . Regulated Expression Validation4021
Field of Research
Immunology
Purification
TSLP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/mL
Buffer
TSLP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TSLP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human TSLP has 2 isoforms, including isoform 1 (159aa, 18kD) and isoform 2 (63aa, 7kD) . Mouse TSLP has one isoform (140aa, 16kD) and rat TSLP also has one isoform (135aa, 16kD) . 4021 can detect only human isoforms, but cannot detect mouse and rat TSLP.
Symbol
TSLP
Positive Control 2
Cat. No. 1303 - Human Brain Tissue Lysate
Positive Control 3
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Thymic stromal lymphopoietin
NCBI Organism
Homo sapiens
Background Reference 01
Ziegler and Liu. Nature Immunol. 2006; 7:709-14.
Background Reference 02
Sims et al. J. Exp. Med. 2000; 192:671-80.
Background Reference 03
Levin et al. J. Immunol. 1999; 162:677-83.
Background Reference 04
Quentmeier et al. Leukemia 2001; 15:1286-92.
Citation 01
PMID: 24850429.
Citation 02
PMID: 30291224.
Citation 03
PMID: 29803543.
Citation 04
PMID: 23550226.
Citation 05
PMID: 24381572.
Citation 06
PMID: 21820713.
Citation 07
PMID: 20107175.
Citation 08
PMID: 19151401.
Other Product Names
TSLP Antibody: Thymic stromal lymphopoietin
Tested Applications
ELISA, WB, IHC-P
Protein ID
14719428
Physical Properties
Liquid

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