Lipe Antibody

CAT: 0223-3965-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3965-01Size:0.02 mg
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Background
Lipe Antibody: Although initially described as an adipocyte-specific triacylglycerol lipase, Lipe (also known as hormone-specific lipase or HSL) is expressed in multiple tissues and cell lines. It plays multiple roles in lipid metabolism, including hormone-stimulated lipolysis in adipose tissue and the hydrolysis of cholesterol esters. Lipe is expressed as a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesterol esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. Recently, it was observed that the lack of Lipe in genetically obese leptin-null mice inhibited obesity and adipogenesis, suggesting that Lipe plays a major role in adipocyte proliferation.
NCBI Gene ID
3991
Swiss Prot
Q05469
Accession Number
ABA03168
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
Lipe Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1369 - Human Lymph node Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (93%)
Buffer
Lipe Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Lipe antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Multiple isoforms of Lipe are known to exist.
Symbol
LIPE
Positive Control 2
Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide
NCBI Official Name
Lipase, hormone-sensitive
NCBI Organism
Homo sapiens
Background Reference 01
Yeaman SJ. Hormone-sensitive lipase - new roles for an old enzyme. Biochem. J. 2004; 379:11-22.
Background Reference 02
Holst LS, Langin D, Mulder H, et al. Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase. Genomics 1996; 35:441-7.
Background Reference 03
Kraemer FB, Shen WJ, Harada K, et al. Hormone-sensitive lipase is required for high-density lipoprotein cholesterol ester-supported adrenal steroidogenesis. Mol. Endocrinol. 2004; 18:549-57.
Background Reference 04
Sekiya M, Osuga J, Okazaki H, et al. Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice. J. Biol. Chem.2004; 279:15084-90.
Other Product Names
Lipe Antibody: HSL, LHS, Hormone-sensitive lipase, HSL
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
896474
Physical Properties
Liquid

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