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Cyclin O Antibody

CAT: 0223-3861-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3861-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member.
NCBI Gene ID
10309
Swiss Prot
P22674
Accession Number
NP_066970
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
Cyclin O Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1310 - Human Bladder Tissue Lysate
Concentration
1 mg/mL
Buffer
Cyclin O Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Cyclin O antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
IgG
Specificity
At least two isoforms of Cyclin O are known to exist; this antibody will recognize both isoforms.
Symbol
CCNO
NCBI Official Name
Cyclin O
NCBI Organism
Homo sapiens
Background Reference 01
Roig MB, Roset R, Ortet L, et al. Identification of a novel cyclin required for the intrinsic apoptosis pathway in lymphoid cells. Cell Death Diff. 2009; 16:230-43.
Background Reference 02
Muller SJ and Caradonna S. Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. Biochim. Biophys. Acta 1991; 1088:197-207.
Background Reference 03
Muller SJ and Caradonna S. Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. J. Biol. Chem. 1993; 268:1310-9.
Other Product Names
Cyclin O Antibody: CCNU, UDG2, Cyclin-O
Tested Applications
ELISA, WB
Protein ID
153791755
Physical Properties
Liquid

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