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BAP31 Antibody

CAT: 0223-3665-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3665-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BAP31 Antibody: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death.
NCBI Gene ID
10134
Swiss Prot
P51572
Accession Number
NP_005736
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
3665
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
BAP31 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1225 - Ramos Cell Lysate
Concentration
1 mg/mL
Buffer
BAP31 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BAP31 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human BAP31 has 2 isoforms, including isoform 1 (246aa, 28kD) and isoform 2 (313aa, 34.8kD) . Mouse BAP31 has one isoform (245aa, 28kD) and Rat BAP31 also has one isoform (245aa, 28kD) . 3665 can detect human, mouse and rat.
Symbol
BCAP31
Positive Control 2
Cat. No. 1462 - Rat Lung Tissue Lysate
Positive Control 3
Cat. No. 1201 - HeLa Cell Lysate
Positive Control 4
Cat. No. 1282 - 3T3/NIH Cell Lysate
NCBI Official Name
B-cell receptor-associated protein 31
NCBI Organism
Homo sapiens
Background Reference 01
Ng et al. J. Cell Biol.1997; 139:327-38.
Background Reference 02
Kim et al. EMBO J.1994; 13:3793-800.
Background Reference 03
Paquet et al. J. Immunol.2004; 172:7548-55.
Background Reference 04
Zen et al. J. Biol. Chem.2004; 279:44924-30.
Other Product Names
BAP31 Antibody: CDM, DDCH, BAP31, 6C6-AG, DXS1357E, B-cell receptor-associated protein 31, 6C6-AG tumor-associated antigen, BCR-associated protein 31
Tested Applications
ELISA, WB, IHC-P
Protein ID
32171186
Physical Properties
Liquid

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