TLR6 Antibody

• Background :

  TLR6 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses.

• NCBI Gene ID :

  10333

• Swiss Prot :

  Q9Y2C9

• Accession Number :

  NP_006059

• Host :

  Rabbit

• Reactivity :

  Human

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  TLR6 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  TLR6 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  TLR6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  TLR6

• Positive Control 2 :

  Cat. No. 17-005 - Jurkat Cell Slide

• NCBI Official Name :

  Toll-like receptor 6

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol.2003; 21:335-76.

• Background Reference 02 :

  Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol.2002; 20:197-216.

• Background Reference 03 :

  McGettrick AF and O'Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm.2004; 41:577-82.

• Background Reference 04 :

  Takeuchi O, Kawai T, Sanjo H, et al. TLR6: A novel member of an expanding Toll-like receptor family. Gene 1999; 231:59-65.

• Other Product Names :

  TLR6 Antibody: CD286, Toll-like receptor 6

• Tested Applications :

  ELISA, WB, ICC

• Protein ID :

  20143971

• Physical Properties :

  Liquid