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CTRP1 Antibody

CAT: 0223-3557-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3557-01Size:0.02 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CTRP1 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.
NCBI Gene ID
114897
Swiss Prot
Q9BXJ1
Accession Number
NP_940995
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
CTRP1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Buffer
CTRP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CTRP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
These proteins are often highly modified post-translationally and migrate in SDS-PAGE at positions other than their predicted size.
Symbol
C1QTNF1
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
C1q and tumor necrosis factor related protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005; 115:911-9.
Background Reference 02
Tsao T-S, Lodish HF, and Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Euro. J. Pharmacol. 2002; 440:213-21.
Background Reference 03
Wong GW, Wang J, Hug C, et al. A family of Acrp30/ adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA 2004; 101:10302-7.
Background Reference 04
Shapiro L and Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 1998; 8:335-8.
Other Product Names
CTRP1 Antibody: GIP, CTRP1, ZSIG37, UNQ310/PRO353, Complement C1q tumor necrosis factor-related protein 1, G protein-coupled receptor-interacting protein, GIP
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
38372917
Physical Properties
Liquid

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