SARS-CoV Envelope Antibody

• Background:

  SARS Envelope Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome) . Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2. Envelope protein is a small polypeptide that contains at least one α-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication.

• NCBI Gene ID:

  1489671

• Swiss Prot:

  P59637

• Accession Number:

  P59637

• Host:

  Rabbit

• Reactivity:

  Virus

• Immunogen:

  3533

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Infectious Disease, COVID-19

• Purification:

  SARS-CoV Envelope Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Homology:

  Predicted reactivity based on immunogen sequence: SARS-CoV-2 Envelope protein: (identity 82%, homology 91%)

• Buffer:

  SARS-CoV Envelope Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SARS-CoV Envelope antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Applications Notes:

  SARS-CoV Envelope antibody can be used for the detection of SARS-CoV Envelope protein in ELISA. It will detect 5 ng of free peptide at 1 μ g/mL.

• Isoform:

  SARS-CoV Envelope has one isoform (75aa) .

• Symbol:

  E

• NCBI Official Name:

  Envelope small membrane protein

• NCBI Organism:

  SARS coronavirus

• Background Reference 01:

  Marra et al. Science 2003;300:1399-404.

• Background Reference 02:

  Rota et al. Science 2003;300:1394-9.

• Background Reference 03:

  Navas-Nartin et al. J Neurovirol. 2004;10:75-85.

• Background Reference 04:

  Pervushin et al. PLoS Pathog. 2009; 5 (7) : e1000511.

• Citation 01:

  18753196

• Other Product Names:

  SARS-CoV Envelope Antibody: sM, 4, Envelope small membrane protein, E protein

• Tested Applications:

  ELISA

• Protein ID:

  30173401

• Physical Properties:

  Liquid