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SARS-CoV Envelope Antibody

CAT: 0223-3533-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3533-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SARS Envelope Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome) . Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2. Envelope protein is a small polypeptide that contains at least one α-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication.
NCBI Gene ID
1489671
Swiss Prot
P59637
Accession Number
P59637
Host
Rabbit
Reactivity
Virus
Immunogen
3533
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Infectious Disease, COVID-19
Purification
SARS-CoV Envelope Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Homology
Predicted reactivity based on immunogen sequence: SARS-CoV-2 Envelope protein: (identity 82%, homology 91%)
Buffer
SARS-CoV Envelope Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SARS-CoV Envelope antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Applications Notes
SARS-CoV Envelope antibody can be used for the detection of SARS-CoV Envelope protein in ELISA. It will detect 5 ng of free peptide at 1 μ g/mL.
Isoform
SARS-CoV Envelope has one isoform (75aa) .
Symbol
E
NCBI Official Name
Envelope small membrane protein
NCBI Organism
SARS coronavirus
Background Reference 01
Marra et al. Science 2003;300:1399-404.
Background Reference 02
Rota et al. Science 2003;300:1394-9.
Background Reference 03
Navas-Nartin et al. J Neurovirol. 2004;10:75-85.
Background Reference 04
Pervushin et al. PLoS Pathog. 2009; 5 (7) : e1000511.
Citation 01
18753196
Other Product Names
SARS-CoV Envelope Antibody: sM, 4, Envelope small membrane protein, E protein
Tested Applications
ELISA
Protein ID
30173401
Physical Properties
Liquid

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