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Caspase-8 Antibody

CAT: 0223-3473-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3473-01Size:0.02 mg
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Background
Caspase-8 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.
NCBI Gene ID
841
Swiss Prot
Q14790
Accession Number
NP_001219
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Neuroscience, Autophagy, Cancer, Inflammasomes
Purification
Caspase-8 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/mL
Buffer
Caspase-8 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Caspase-8 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
55 kDa
Fragment
IgG
Specificity
Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
Symbol
CASP8
Positive Control 2
Cat. No. 1306 - Human Spleen Tissue Lysate
Positive Control 3
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Positive Control 4
Cat. No. 1466 - Rat Spleen Tissue Lysate
Positive Control 5
Cat. No. 10-901 - Human Spleen Tissue Slide
Positive Control 6
Cat. No. 17-005 - Jurkat Cell Slide
NCBI Official Name
Caspase 8, apoptosis-related cysteine peptidase
NCBI Organism
Homo sapiens
Background Reference 01
Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.
Background Reference 02
Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.
Background Reference 03
Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.
Background Reference 04
Muzio M, Chinnaiyan AM, Kischkel FC, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996; 85:817-27.
Other Product Names
Caspase-8 Antibody: CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8, Caspase-8, Apoptotic cysteine protease, CASP-8
Tested Applications
ELISA, WB, IHC-P, ICC, IF
Protein ID
15718704
Physical Properties
Liquid

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