Caspase-4 Antibody

• Background:

  Caspase-4 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease.

• NCBI Gene ID:

  837

• Swiss Prot:

  P49662

• Accession Number:

  AAA86890

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Neuroscience, Inflammasomes

• Purification:

  Caspase-4 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (73%)

• Buffer:

  Caspase-4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Caspase-4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  Depending on cell lines or tissues used, other cleavage products may be observed.

• Symbol:

  CASP4

• Positive Control 2:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• Positive Control 3:

  Cat. No. 17-208 - A-20 Cell Slide

• NCBI Official Name:

  Caspase 4, apoptosis-related cysteine peptidase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

• Background Reference 02:

  Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 β converting enzyme. Science 1995; 267:2000-3.

• Background Reference 03:

  Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.

• Background Reference 04:

  Kamens J, Paskind M, Hugunin M, et al. Identification and characterization of ICH-2, a novel member of the interleukin-1 β -converting enzyme family of cysteine proteases. J. Biol. Chem. 1995; 270:15250-6.

• Other Product Names:

  Caspase-4 Antibody: TX, ICH-2, Mih1/TX, ICEREL-II, ICE (rel) II, ICH2, Caspase-4, Protease ICH-2, CASP-4

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  886050

• Physical Properties:

  Liquid