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Caspase-4 Antibody

CAT: 0223-3453-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3453-01Size:0.02 mg
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Background
Caspase-4 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease.
NCBI Gene ID
837
Swiss Prot
P49662
Accession Number
AAA86890
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Neuroscience, Inflammasomes
Purification
Caspase-4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (73%)
Buffer
Caspase-4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Caspase-4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Depending on cell lines or tissues used, other cleavage products may be observed.
Symbol
CASP4
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
Positive Control 3
Cat. No. 17-208 - A-20 Cell Slide
NCBI Official Name
Caspase 4, apoptosis-related cysteine peptidase
NCBI Organism
Homo sapiens
Background Reference 01
Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.
Background Reference 02
Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 β converting enzyme. Science 1995; 267:2000-3.
Background Reference 03
Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.
Background Reference 04
Kamens J, Paskind M, Hugunin M, et al. Identification and characterization of ICH-2, a novel member of the interleukin-1 β -converting enzyme family of cysteine proteases. J. Biol. Chem. 1995; 270:15250-6.
Other Product Names
Caspase-4 Antibody: TX, ICH-2, Mih1/TX, ICEREL-II, ICE (rel) II, ICH2, Caspase-4, Protease ICH-2, CASP-4
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
886050
Physical Properties
Liquid

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