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TIRP Antibody

CAT: 0223-3299-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3299-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TIRP Antibody: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF) -6, and ultimately the activation of NF-κ B. Expression of TIRP appears to be essential for TLR4 signalling.
NCBI Gene ID
353376
Swiss Prot
Q86XR7
Accession Number
AAP81748
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
TIRP Antibody is Ion exchange chromatography purified.
Positive Control
Cat. No. 1324 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Buffer
TIRP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TIRP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TICAM2
Positive Control 2
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Positive Control 3
Cat. No. 1465 - Rat Kidney Tissue Lysate
NCBI Official Name
Toll-like receptor adaptor molecule 2
NCBI Organism
Homo sapiens
Background Reference 01
O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003;24:286-9.
Background Reference 02
Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003;3:466-77.
Background Reference 03
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003;21:335-76.
Background Reference 04
Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002;20:197-216.
Other Product Names
TIRP Antibody: TIRP, TRAM, TIRAP3, MyD88-4, TICAM-2, TIRP, TIR domain-containing adapter molecule 2, Putative NF-kappa-B-activating protein 502
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
32435943
Physical Properties
Liquid

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