Products for Research Use Only
RegisterLogin

TRIM5 alpha Antibody

CAT: 0223-3249-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-3249-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
TRIM5 alpha Antibody: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5α variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5α variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5α acts as a natural barrier to cross-species retrovirus transmission.
NCBI Gene ID
574288
Swiss Prot
Q0PF16
Accession Number
ABG67967
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease
Purification
TRIM5 alpha Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1319 - Human Stomach Tissue Lysate
Concentration
1 mg/mL
Buffer
TRIM5 alpha Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TRIM5 alpha antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Anti-TRIM5 alpha is human reactive but should presumably also react with rhesus protein.
Symbol
TRIM5
Positive Control 2
Cat. No. 1317 - Human Uterus Tissue Lysate
Positive Control 3
Cat. No. 1314 - Human Thymus Tissue Lysate
Positive Control 4
Cat. No. 10-001 - Human Breast Tissue Slide
NCBI Official Name
Tripartite motif-containing 5
NCBI Organism
Macaca mulatta
Background Reference 01
Reymond A, Meroni G, Fantozzi A, et al. The tripartite motif family identifies cell compartments. EMBO J. 2001; 20:2140-51.
Background Reference 02
Stremlau M, Owens CM, Perron MJ, et al. The cytoplasmic body component TRIM5a restricts HIV-1 infection in Old World monkeys. Nature 2004; 427:848-53.
Background Reference 03
Hatziioannou T, Perez-Caballero D, Yang A, et al. Retrovirus resistance factors REF1 and Lv1 are species-specific variants of TRIM5α . Proc. Nat'l. Acad. Sci. USA 2004; 101:10774-9
Other Product Names
TRIM5 alpha Antibody: RNF88, TRIM5alpha, RNF88, Tripartite motif-containing protein 5, RING finger protein 88
Tested Applications
ELISA, WB, IF
Protein ID
110339457
Physical Properties
Liquid

Related Products

CatalogName
3249PTRIM5 alpha Peptide
3251PTRIM5 alpha (IN2) Peptide
3247PTRIM5 alpha (IN1) Peptide
46-526TRIM5 Antibody
45-163TRIM5 Antibody
3241-01mgTRIM5 delta Antibody
3239-002mgTRIM5 gamma Antibody
3241-01TRIM5 delta Antibody
3239-01TRIM5 gamma Antibody
3239-01mgTRIM5 gamma Antibody

Alternative Products

CatalogName
BF0206-01Trim5 alpha Antibody
TA382831TRIM5 alpha (TRIM5) Rabbit Polyclonal Antibody
TA302865TRIM5 alpha (TRIM5) Goat Polyclonal Antibody
JOT-MCA1231-01TRIM5 Alpha Monoclonal Antibody
TS413880P5TRIM5 alpha (TRIM5) CytoSection
529293-01Trim5 alpha

Popular Products