CARMA2 Antibody

CAT: 0223-3191-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3191-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CARMA2 Antibody: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κ B activation. When expressed in cells, this protein activated NF-κ B and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-κ B activation and endoplasmic reticulum stress-induced cell death.
NCBI Gene ID
79092
Swiss Prot
Q9BXL6
Accession Number
NP_077015
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
CARMA2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (92%)
Buffer
CARMA2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CARMA2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
CARMA2 antibody is human specific. At least three isoforms of CARMA2 are known to exist; this antibody will only detect isoform 1. CARMA2 antibody is predicted not to cross-react with other CARMA proteins.
Symbol
CARD14
NCBI Official Name
Caspase recruitment domain family, member 14
NCBI Organism
Homo sapiens
Background Reference 01
Fanning AS and Anderson JM. Protein modules as organizers of membrane structure. Curr. Opin. Cell Biol. 1999; 11:432-9.
Background Reference 02
Gaide O, Martinon F, Michau O, et al. Carma1, 1 CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappa B activation. FEBS Lett. 2001; 496:121-7.
Background Reference 03
Bertin J, Wang L, Guo Y, et al. CARD11 and CARD14 are novel caspase recruitment domain (CARD) /membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. J. Biol. Chem. 2001; 276:11877-82.
Background Reference 04
Scudiero I, Zotti T, Ferravante A, et al. Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kB activation endoplasmic reticulum stress-induced cell death. J. Cell Physiol. 2011; 226:3121-31.
Other Product Names
CARMA2 Antibody: PRP, PSS1, BIMP2, CARMA2, PSORS2, Caspase recruitment domain-containing protein 14, CARD-containing MAGUK protein 2, Carma 2
Tested Applications
ELISA, IHC-P
Protein ID
332801087
Physical Properties
Liquid

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