TLR4 Antibody

• Background:

  TLR4 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κ B. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

• NCBI Gene ID:

  7099

• Swiss Prot:

  O00206

• Accession Number:

  NP_612564

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity, Inflammasomes

• Purification:

  TLR4 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1308 - Human Small Intestine Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (80%), Horse: (73%), Rat: (71%), Pig: (73%)

• Buffer:

  TLR4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TLR4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TLR4

• Positive Control 2:

  Cat. No. 1204 - K562 Cell Lysate

• Positive Control 3:

  Cat. No. 17-004 - K-562 Cell Slide

• NCBI Official Name:

  Toll-like receptor 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.

• Background Reference 02:

  Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.

• Background Reference 03:

  Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.

• Background Reference 04:

  O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.

• Other Product Names:

  TLR4 Antibody: TOLL, CD284, TLR-4, ARMD10, Toll-like receptor 4, hToll

• Tested Applications:

  ELISA, WB, ICC, IHC-P, IF

• Protein ID:

  19924149

• Physical Properties:

  Liquid