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NALP2 Antibody

CAT: 0223-3027-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3027-01Size:0.02 mg
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Background
NALP2 Antibody: NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD) . This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1β -processing activity and is thought to function as a modulator of NF-κ B and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs) . At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
NCBI Gene ID
55655
Swiss Prot
Q9NX02
Accession Number
NP_060322
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Innate Immunity
Purification
NALP2 Antibody is immunoaffinity chromatography purified IgG.
Positive Control
Cat. No. 1216 - PC-3 Cell Lysate
Concentration
1 mg/mL
Buffer
NALP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NALP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
NLRP2
NCBI Official Name
NLR family, pyrin domain containing 2
NCBI Organism
Homo sapiens
Background Reference 01
Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 2003; 4:95-104.
Background Reference 02
Bruey JM, Bruey-Sedano N, Newman R, et al. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-κ B and caspase-1 activation in macrophages. J. Biol. Chem. 2004; 279:51897-907.
Background Reference 03
Agostini L, Martinon F, Burns K, et al. NALP3 forms an IL-1β -processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004; 20:319-25.
Background Reference 04
Martinon F and Tschopp J. NLRs join TLRs as innate sensors of pathogens. TRENDS Imm. 2005; 26:447-54.
Other Product Names
NALP2 Antibody: NBS1, PAN1, NALP2, PYPAF2, CLR19.9, NBS1, NACHT, LRR and PYD domains-containing protein 2, Nucleotide-binding site protein 1
Tested Applications
ELISA, WB
Protein ID
8923473
Physical Properties
Liquid

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