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KLHL1 Antibody

CAT: 0223-3015-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3015-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
KLHL1 Antibody: The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins. Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.
NCBI Gene ID
57626
Swiss Prot
Q9NR64
Accession Number
AAF81719
Host
Rabbit
Reactivity
Human, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
KLHL1 Antibody is immunoaffinity purified .
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (100%)
Buffer
KLHL1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KLHL1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
KLHL1
Positive Control 2
Cat. No. 1403 - Mouse Brain Tissue Lysate
NCBI Official Name
Kelch-like 1 (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Nemes JP, Benzo KA, and Koob MD. The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1) . Human Mol. Gen. 2000; 9:1543-51.
Background Reference 02
Adams J, Kelso R, and Cooley L. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol. 2000; 10:17-24.
Background Reference 03
Robinson DN and Cooley L. Drosophila kelch is an oligomeric ring canal actin organizer. J. Cell Biol. 1997; 138:799-810.
Other Product Names
KLHL1 Antibody: MRP2, KIAA1490, Kelch-like protein 1
Tested Applications
ELISA, WB, IHC-P
Protein ID
8926179
Physical Properties
Liquid

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