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CARD10 Antibody

CAT: 0223-3013-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3013-01Size:0.02 mg
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Background
CARD10 Antibody: Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10. This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-κ B. CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the Iκ K complex, demonstrating its importance in the regulation of NF-κ B transcription factor activation.
NCBI Gene ID
29775
Swiss Prot
Q9BWT7
Accession Number
AAK26165
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
CARD10 Antibody is immunoaffinity purified .
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Buffer
CARD10 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CARD10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
CARD10
Positive Control 2
Cat. No. 1288 - A20 Cell Lysate
Positive Control 3
Cat. No. 17-207 - EL4 Cell Slide
NCBI Official Name
Caspase recruitment domain family, member 10
NCBI Organism
Homo sapiens
Background Reference 01
Wang L, Guo Y, Huang W-J, et al. CARD10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappaB. J. Biol. Chem. 2001; 276:21405-9.
Background Reference 02
Fanning AS and Anderson JM. Protein modules as organizers of membrane structure. Curr. Opin. Cell Biol. 1999; 11:432-9.
Background Reference 03
Fischer KD, Tedford K, Wirth T. New roles for Bcl10 in B-cell development and LPS response. Trends Immunol. 2004; 25:113-6.
Background Reference 04
Stilo R, Liguoro D, Di Jeso B, et al. Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase kappa-NF-kappaB essential modulator. J. Biol. Chem. 2004; 279:34323-31.
Other Product Names
CARD10 Antibody: BIMP1, CARMA3, Caspase recruitment domain-containing protein 10, CARD-containing MAGUK protein 3, Carma 3
Tested Applications
ELISA, WB, ICC, IF
Protein ID
13488607
Physical Properties
Liquid

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