IRAK-M Antibody

• Background:

  IRAK-M Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR) . IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.

• NCBI Gene ID:

  11213

• Swiss Prot:

  Q9Y616

• Accession Number:

  NP_009130

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  IRAK-M Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1406 - Mouse Spleen Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  IRAK-M Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  IRAK-M antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  IRAK-M antibody is predicted to have no cross reactivity to other members of the IRAK family.

• Symbol:

  IRAK3

• Positive Control 2:

  Cat. No. 1465 - Rat Kidney Tissue Lysate

• Positive Control 3:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  Interleukin-1 receptor-associated kinase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Cao Z, Henzel WJ, and Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 1996; 271:1128-31.

• Background Reference 02:

  Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997; 278:1612-5.

• Background Reference 03:

  Wesche H, Gao X, Li X, et al. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 1999; 274:19403-10.

• Other Product Names:

  IRAK-M Antibody: ASRT5, IRAKM, Interleukin-1 receptor-associated kinase 3, IL-1 receptor-associated kinase M, IRAK-3

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  5225377

• Physical Properties:

  Liquid