CIDE-B Antibody

• Background :

  CIDE-B Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes and bone marrow.

• NCBI Gene ID :

  27141

• Swiss Prot :

  Q9UHD4

• Accession Number :

  AF218586

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis

• Purification :

  CIDE-B Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1408 - Mouse Small Intestine Tissue Lysate

• Concentration :

  1 mg/ml

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine: (86%)

• Buffer :

  CIDE-B Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  CIDE-B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  CIDE-B antibody has no cross activity to CIDE-A.

• Symbol :

  CIDEB

• Positive Control 2 :

  Cat. No. 1308 - Human Small Intestine Tissue Lysate

• Positive Control 3 :

  Cat. No. 11-801 - Human Small Intestine Tissue Slide

• NCBI Official Name :

  Cell death-inducing DFFA-like effector b

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Inohara N, Koseki T, Chen S, et al. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998; 17:2526-33.

• Background Reference 02 :

  Inohara N, Koseki T, Chen S, et al. Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD. J. Biol. Chem.1999; 274:270-4.

• Other Product Names :

  CIDE-B Antibody: CIDE-B, AI790179, 1110030C18Rik, Cell death activator CIDE-B, Cell death-inducing DFFA-like effector B

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  6746626

• Physical Properties :

  Liquid