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DcR2 Antibody

CAT: 0223-2021-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2021-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DcR2 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.
NCBI Gene ID
8793
Swiss Prot
Q9UBN6
Accession Number
Q9UBN6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
KD validation (Figure 7) : Anti-ASC antibody (2287) specificity was further verified by ASC specific knockdown. ASC signal in THP-1 cells transfected with ASC siRNAs was disrupted in comparison with that in cells transfected with GFP siRNAs. KD validation2287
Field of Research
Apoptosis
Purification
DcR2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
DcR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DcR2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TNFRSF10D
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
NCBI Organism
Homo sapiens
Background Reference 01
Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997; 276:111-3.
Background Reference 02
Pan G, Ni J, Wei YF, Yu G, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997; 277:815-8.
Background Reference 03
Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 1997; 277:818-21.
Background Reference 04
Marsters SA, Sheridan JP, Pitti RM, et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 1997; 7:1003-6.
Other Product Names
DcR2 Antibody: DCR2, CD264, TRUNDD, TRAILR4, TRAIL-R4, DCR2, UNQ251/PRO288, Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2
Tested Applications
ELISA, WB, ICC, IHC-P, IF
Protein ID
18203495
Physical Properties
Liquid

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