Fbxo2 (NM_176848) Mouse Recombinant Protein

• Background:

  Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  FBG1; Fbs1; Fbs2; FBX2; NFB42; Prpl4

• Gene ID:

  230904

• UniProt:

  Q80UW2, Q3USR5

• Accession Number mRNA:

  NM_176848

• Chromosomal Location:

  4 78.68 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  33.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Fbxo2

• Species:

  Mouse

• Protein ID:

  NP_789818

• Overview:

  Purified recombinant protein of Mouse F-box protein 2 (Fbxo2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/230904

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q80UW2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_176848

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_789818