HSPC152 (TRMT112) (NM_016404) Human Recombinant Protein

• Background:

  Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604) . Together with methyltransferase BUD23, methylates the N (7) position of a guanine in 18S rRNA (PubMed:25851604) . The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146) . The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323) . Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  HSPC152; HSPC170; hTrm112; TRM112; TRMT11-2

• Gene ID:

  51504

• UniProt:

  Q9UI30, A0A024R565

• Accession Number mRNA:

  NM_016404

• Chromosomal Location:

  11q13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  14 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TRMT112

• Species:

  Human

• Protein ID:

  NP_057488

• Overview:

  Recombinant protein of human hypothetical protein HSPC152 (HSPC152)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51504

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UI30

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_016404

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057488