PPP2R1A (NM_014225) Human Recombinant Protein

• Background:

  This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

• Synonyms:

  MRD36; PP2A-Aalpha; PP2AA; PP2AAALPHA; PR65A

• Gene ID:

  5518

• UniProt:

  P30153, A8K7B7

• Accession Number mRNA:

  NM_014225

• Chromosomal Location:

  19q13.41

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Long-term depression, Oocyte meiosis, TGF-beta signaling pathway, Tight junction, Wnt signaling pathway

• Field of Research:

  Long-term depression, Oocyte meiosis, TGF-beta signaling pathway, Tight junction, Wnt signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Phosphatase, Transcription Factors

• Molecular Weight:

  65.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PPP2R1A

• Species:

  Human

• Protein ID:

  NP_055040

• Overview:

  Recombinant protein of human protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform (PPP2R1A)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5518

• Uniprot URL:

  https://www.uniprot.org/uniprot/P30153

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_014225

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_055040