Transglutaminase 2 (TGM2) (NM_198951) Human Recombinant Protein

• Background:

  Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  G-ALPHA-h; GNAH; HEL-S-45; TG2; TGC

• Gene ID:

  7052

• UniProt:

  P21980

• Accession Number mRNA:

  NM_198951

• Chromosomal Location:

  20q11.23

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Huntington's disease

• Field of Research:

  Huntington's disease

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  61.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TGM2

• Species:

  Human

• Protein ID:

  NP_945189

• Overview:

  Recombinant protein of human transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) (TGM2), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7052

• Uniprot URL:

  https://www.uniprot.org/uniprot/P21980

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_198951

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_945189