HRASLS3 (PLA2G16) (NM_007069) Human Recombinant Protein

• Background:

  Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625) . Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616) . For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464) . Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464) . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381) . Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AdPLA; H-REV107; H-REV107-1; HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16; PLAAT-3

• Gene ID:

  11145

• UniProt:

  P53816, A0A024R561

• Accession Number mRNA:

  NM_007069

• Chromosomal Location:

  11q12.3-q13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  17.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PLA2G16

• Species:

  Human

• Protein ID:

  NP_009000

• Overview:

  Recombinant protein of human phospholipase A2, group XVI (PLA2G16), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/11145

• Uniprot URL:

  https://www.uniprot.org/uniprot/P53816

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007069

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_009000