STUB1 (NM_005861) Human Recombinant Protein

• Background:

  This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

• Synonyms:

  CHIP; HSPABP2; NY-CO-7; SCA48; SCAR16; SDCCAG7; UBOX1

• Gene ID:

  10273

• UniProt:

  Q9UNE7

• Accession Number mRNA:

  NM_005861

• Chromosomal Location:

  16p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Ubiquitin mediated proteolysis

• Field of Research:

  Ubiquitin mediated proteolysis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  34.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  STUB1

• Species:

  Human

• Protein ID:

  NP_005852

• Overview:

  Recombinant protein of human STIP1 homology and U-box containing protein 1 (STUB1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10273

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UNE7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005861

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005852