MATK (NM_139354) Human Recombinant Protein

• Background:

  The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  CHK; CTK; HHYLTK; HYL; HYLTK; Lsk

• Gene ID:

  4145

• UniProt:

  P42679

• Accession Number mRNA:

  NM_139354

• Chromosomal Location:

  19p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase, Stem cell - Pluripotency

• Molecular Weight:

  51.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MATK

• Species:

  Human

• Protein ID:

  NP_647611

• Overview:

  Recombinant protein of human megakaryocyte-associated tyrosine kinase (MATK), transcript variant 3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4145

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42679

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_139354

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_647611