HPRT (HPRT1) (NM_000194) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]

• Synonyms:

  HGPRT; HPRT

• Gene ID:

  3251

• UniProt:

  P00492, A0A140VJL3

• Accession Number mRNA:

  NM_000194

• Chromosomal Location:

  Xq26.2-q26.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

• Field of Research:

  Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Stem cell - Pluripotency

• Molecular Weight:

  24.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HPRT1

• Species:

  Human

• Protein ID:

  NP_000185

• Overview:

  Recombinant protein of human hypoxanthine phosphoribosyltransferase 1 (HPRT1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3251

• Uniprot URL:

  https://www.uniprot.org/uniprot/P00492

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000194

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000185