DAB2 (NM_001343) Human Recombinant Protein

• Background:

  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Synonyms:

  DOC-2; DOC2

• Gene ID:

  1601

• UniProt:

  P98082, A0A024R036, B2RAW0

• Accession Number mRNA:

  NM_001343

• Chromosomal Location:

  5p13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis

• Field of Research:

  Endocytosis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  82.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DAB2

• Species:

  Human

• Protein ID:

  NP_001334

• Overview:

  Recombinant protein of human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1601

• Uniprot URL:

  https://www.uniprot.org/uniprot/P98082

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001343

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001334