DUSP14 (NM_007026) Human Recombinant Protein

• Background:

  Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]) .[supplied by OMIM, Dec 2009]

• Synonyms:

  MKP-L; MKP6

• Gene ID:

  11072

• UniProt:

  O95147, Q6FI36

• Accession Number mRNA:

  NM_007026

• Chromosomal Location:

  17q12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  MAPK signaling pathway

• Field of Research:

  MAPK signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Phosphatase

• Molecular Weight:

  22.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DUSP14

• Species:

  Human

• Protein ID:

  NP_008957

• Overview:

  Recombinant protein of human dual specificity phosphatase 14 (DUSP14)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/11072

• Uniprot URL:

  https://www.uniprot.org/uniprot/O95147

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007026

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_008957