NQO1 (NM_000903) Human Recombinant Protein

• Background:

  This gene is a member of the NAD (P) H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD) . Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Synonyms:

  DHQU; DIA4; DTD; NMOR1; NMORI; QR1

• Gene ID:

  1728

• UniProt:

  P15559

• Accession Number mRNA:

  NM_000903

• Chromosomal Location:

  16q22.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  30.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NQO1

• Species:

  Human

• Protein ID:

  NP_000894

• Overview:

  Recombinant protein of human NAD (P) H dehydrogenase, quinone 1 (NQO1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1728

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15559

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000903

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000894