IFNGR2 (NM_005534) Human Recombinant Protein

• Background:

  This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

• Synonyms:

  AF-1; IFGR2; IFNGT1; IMD28

• Gene ID:

  3460

• UniProt:

  P38484, A8K881

• Accession Number mRNA:

  NM_005534

• Chromosomal Location:

  21q22.11

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity

• Field of Research:

  Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  35 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  IFNGR2

• Species:

  Human

• Protein ID:

  NP_005525

• Overview:

  Recombinant protein of human interferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3460

• Uniprot URL:

  https://www.uniprot.org/uniprot/P38484

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005534

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005525