HMGB2 (NM_002129) Human Recombinant Protein

• Background:

  This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V (D) J recombination. [provided by RefSeq, Jul 2008]

• Synonyms:

  HMG2

• Gene ID:

  3148

• UniProt:

  P26583

• Accession Number mRNA:

  NM_002129

• Chromosomal Location:

  4q34.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  23.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HMGB2

• Species:

  Human

• Protein ID:

  NP_002120

• Overview:

  Recombinant protein of human high-mobility group box 2 (HMGB2), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3148

• Uniprot URL:

  https://www.uniprot.org/uniprot/P26583

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002129

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002120