TTLL12 (NM_015140) Human Recombinant Protein

• Background:

  Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473) . Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473) . Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473) . During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  DJ526I14.2

• Gene ID:

  23170

• UniProt:

  Q14166, A0A024R4U3

• Accession Number mRNA:

  NM_015140

• Chromosomal Location:

  22q13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  74.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TTLL12

• Species:

  Human

• Protein ID:

  NP_055955

• Overview:

  Recombinant protein of human tubulin tyrosine ligase-like family, member 12 (TTLL12)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/23170

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q14166

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015140

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_055955