DARPP32 (PPP1R1B) (NM_181505) Human Recombinant Protein

• Background:

  This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Synonyms:

  DARPP-32; DARPP32

• Gene ID:

  84152

• UniProt:

  Q9UD71, A0A024R1R3

• Accession Number mRNA:

  NM_181505

• Chromosomal Location:

  17q12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  18.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PPP1R1B

• Species:

  Human

• Protein ID:

  NP_852606

• Overview:

  Recombinant protein of human protein phosphatase 1, regulatory (inhibitor) subunit 1B (PPP1R1B), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/84152

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UD71

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_181505

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_852606