Suppressor of Fused (SUFU) (NM_016169) Human Recombinant Protein

• Background:

  The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

• Synonyms:

  JBTS32; PRO1280; SUFUH; SUFUXL

• Gene ID:

  51684

• UniProt:

  Q9UMX1

• Accession Number mRNA:

  NM_016169

• Chromosomal Location:

  10q24.32

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

• Field of Research:

  Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  53.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SUFU

• Species:

  Human

• Protein ID:

  NP_057253

• Overview:

  Recombinant protein of human suppressor of fused homolog (Drosophila) (SUFU)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51684

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UMX1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_016169

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057253