Integrin alpha 5 (ITGA5) (NM_002205) Human Recombinant Protein

• Background:

  The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

• Synonyms:

  CD49e; FNRA; VLA-5; VLA5A

• Gene ID:

  3678

• UniProt:

  P08648, B2R627

• Accession Number mRNA:

  NM_002205

• Chromosomal Location:

  12q13.13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton

• Field of Research:

  Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

• Molecular Weight:

  110 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ITGA5

• Species:

  Human

• Protein ID:

  NP_002196

• Overview:

  Recombinant protein of human integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3678

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08648

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002205

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002196