EIF4EL3 (EIF4E2) (NM_004846) Human Recombinant Protein

• Background:

  Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349) . Acts as a repressor of translation initiation (PubMed:22751931) . In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e

• Gene ID:

  9470

• UniProt:

  O60573, Q53RG0

• Accession Number mRNA:

  NM_004846

• Chromosomal Location:

  2q37.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Insulin signaling pathway, mTOR signaling pathway

• Field of Research:

  Insulin signaling pathway, mTOR signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  28.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  EIF4E2

• Species:

  Human

• Protein ID:

  NP_004837

• Overview:

  Recombinant protein of human eukaryotic translation initiation factor 4E family member 2 (EIF4E2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9470

• Uniprot URL:

  https://www.uniprot.org/uniprot/O60573

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004846

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004837