NOLA1 (GAR1) (NM_018983) Human Recombinant Protein

• Background:

  This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  NOLA1

• Gene ID:

  54433

• UniProt:

  Q9NY12

• Accession Number mRNA:

  NM_018983

• Chromosomal Location:

  4q25

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Stem cell - Pluripotency

• Molecular Weight:

  22.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GAR1

• Species:

  Human

• Protein ID:

  NP_061856

• Overview:

  Recombinant protein of human GAR1 ribonucleoprotein homolog (yeast) (GAR1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/54433

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NY12

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_018983

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_061856