PPAR gamma (PPARG) (NM_138712) Human Recombinant Protein

• Background:

  This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

• Synonyms:

  CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma

• Gene ID:

  5468

• UniProt:

  P37231, D2KUA6

• Accession Number mRNA:

  NM_138712

• Chromosomal Location:

  3p25.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Huntington's disease, Pathways in cancer, PPAR signaling pathway, Thyroid cancer

• Field of Research:

  Huntington's disease, Pathways in cancer, PPAR signaling pathway, Thyroid cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

• Molecular Weight:

  54.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PPARG

• Species:

  Human

• Protein ID:

  NP_619726

• Overview:

  Recombinant protein of human peroxisome proliferator-activated receptor gamma (PPARG), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5468

• Uniprot URL:

  https://www.uniprot.org/uniprot/P37231

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_138712

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_619726