SH3 containing Grb 2 like 1 protein (SH3GL1) (NM_003025) Human Recombinant Protein

• Background:

  This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

• Synonyms:

  CNSA1; EEN; SH3D2B; SH3P8

• Gene ID:

  6455

• UniProt:

  Q99961, Q6FGM0

• Accession Number mRNA:

  NM_003025

• Chromosomal Location:

  19p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis

• Field of Research:

  Endocytosis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  41.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SH3GL1

• Species:

  Human

• Protein ID:

  NP_003016

• Overview:

  Recombinant protein of human SH3-domain GRB2-like 1 (SH3GL1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6455

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99961

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003025

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003016